RESUMO
INTRODUCTION: During the first 2 years of newborn screening (NBS) for severe combined immunodeficiency (SCID), 39 infants with an abnormal or inconclusive newborn screening test for SCID died prior to assessment of immune function. We investigated if SCID or primary T-cell lymphopenia likely contributed to the death of these neonates. METHODS: This study is a detailed retrospective chart review. RESULTS: Medical records were available in all 39 infants. Three neonates were full-term infants whose deaths were due to congenital anomalies. Thirty-three infants were born <33 weeks estimated gestational age, and the majority of these infants died from complications of prematurity. Six infants died from sepsis: two due to maternal chorioamnionitis, two due to necrotizing enterocolitis, one due to early onset group B strep sepsis, and one from a likely nosocomial infection. CONCLUSIONS: There was no evidence that SCID contributed to the cause of death in neonates with an abnormal of inconclusive NBS test for SCID.
Assuntos
Causas de Morte , DNA/análise , Mortalidade Infantil , Imunodeficiência Combinada Severa/mortalidade , Corioamnionite/imunologia , Corioamnionite/mortalidade , Enterocolite Necrosante/imunologia , Enterocolite Necrosante/mortalidade , Feminino , Genes Codificadores dos Receptores de Linfócitos T/imunologia , Humanos , Lactente , Recém-Nascido , Linfopenia , Masculino , Prontuários Médicos , Triagem Neonatal/métodos , Gravidez , Nascimento Prematuro , Estudos Retrospectivos , Sepse/imunologia , Sepse/mortalidade , Imunodeficiência Combinada Severa/genética , Imunodeficiência Combinada Severa/imunologiaRESUMO
Allergic (IgE antibody-mediated) reactions to proteins retained in natural rubber latex (NRL), although decreasing in prevalence, are still a concern in many clinical practices due to possible sensitization of healthcare workers exposed to latex in the office setting and patients with histories of latex allergy who present in the office. In this article, the authors outline the risk factors for latex allergy, describe the symptoms of latex allergy, and provide direction on how to create an environment safe for medical care of latex-allergic patients. In addition, treatment of anaphylaxis to NRL is outlined, including precrisis steps in preparation for anaphylactic reactions in the office surgery setting. Many of the precautions outlined in this article could be extrapolated for a healthcare worker with known or suspected latex allergy.
